OLIG2-IN-1

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme[1].

Product Specifications

UNSPSC

12352005

Target

OLIG2

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC1=NC=NC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=C1

Molecular Formula

C11H9Cl2N5O

Molecular Weight

298.13

References & Citations

[1]Xu Z, et al. Discovery of novel pyrimidine-4,6-diamine-based OLIG2 inhibitors as potent anti-glioblastoma agents. Eur J Med Chem. 2025 Nov 15;298:118009.