KRASG12D-IN-7
KRASG12D-IN-7 is a selective KRASG12D inhibitor. KRASG12D-IN-7 displays strong binding activity for KRASG12D in both its GDP- and GTP- bound states, with Kd value of 1.12 nM and 1.86 nM, respectively. KRASG12D-IN-7 inhibits the proliferation of KRASG12D harboring AsPC-1 cells with an IC50 value of 10 nM and suppresses MAPK signaling. KRASG12D-IN-7 induces G0/G1 phase arrest and apoptosis in AsPC-1 cells, and strongly inhibits their colony formation. KRASG12D-IN-7 can be used for the study of cancers harboring KRASG12D mutation, particularly pancreatic ductal adenocarcinoma (PDAC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ERK; Ras
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#CC1=C(N)[Se]C2=CC=CC(C3=C(F)C4N=C(OC[C@@]56CCCN5C[C@H](F)C6)N=C(N7C[C@H]8N[C@H](CC8)C7)C4C=C3Cl)=C21
Molecular Formula
C31H32ClF2N7OSe
Molecular Weight
671.04
References & Citations
[1]Zhou L, et al. The design and synthesis of selective and potent selenium-containing KRASG12D inhibitors. Eur J Med Chem. 2025 Nov 15;298:118004.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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