Aurora kinase ligand-1

Aurora kinase ligand-1 (Compound I-4) is an Aurora kinase B (AURKB) PROTAC ligand. Aurora kinase ligand-1 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize AURKB PROTAC degrader MS44 (HY-175525) . MS44 can be used for cancer research[1].

Product Specifications

CAS Number

[1907679-70-2]

UNSPSC

12352005

Target

Aurora Kinase; Ligands for Target Protein for PROTAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

OCCNCCCOC1=CC2=NC=NC(NC3=NNC(CC(NC4=CC=CC(F)=C4)=O)=C3)=C2C=C1

Molecular Formula

C24H26FN7O3

Molecular Weight

479.51

References & Citations

[1]Hu X, et al. Discovery of the first-in-class Aurora B kinase selective degrader. Eur J Med Chem. 2025 Nov 15;298:118006.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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