Aurora kinase ligand-1
Aurora kinase ligand-1 (Compound I-4) is an Aurora kinase B (AURKB) PROTAC ligand. Aurora kinase ligand-1 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize AURKB PROTAC degrader MS44 (HY-175525) . MS44 can be used for cancer research[1].
Product Specifications
CAS Number
[1907679-70-2]
UNSPSC
12352005
Target
Aurora Kinase; Ligands for Target Protein for PROTAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OCCNCCCOC1=CC2=NC=NC(NC3=NNC(CC(NC4=CC=CC(F)=C4)=O)=C3)=C2C=C1
Molecular Formula
C24H26FN7O3
Molecular Weight
479.51
References & Citations
[1]Hu X, et al. Discovery of the first-in-class Aurora B kinase selective degrader. Eur J Med Chem. 2025 Nov 15;298:118006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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