MS44
MS44 is a potent aurora kinase B (AURKB PROTAC) degrader (DC50 = 103 nM) . MS44 effectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS) -dependent manner and is selective for AURKB over AURKA and AURKC. MS44 effectively inhibits the proliferation in multiple cancer cell lines and potently induces G2/M arrest. MS44 can be used for the study of AURKB-dependent tumors (Pink: Target protein ligand (HY-175526) ; Blue: E3 ligand (HY-112078) ; Black: Linker; E3 ligand + Linker (HY-132938) ) [1].
Product Specifications
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
Molecular Formula
C57H72FN11O8S
Molecular Weight
1090.31
References & Citations
[1]Hu X, et al. Discovery of the first-in-class Aurora B kinase selective degrader. Eur J Med Chem. 2025 Nov 15;298:118006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B; von Hippel-Lindau (VHL)
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