MAO-B-IN-48

MAO-B-IN-48 is a selective MAO-B inhibitor (IC50 = 0.09 μM, Ki = 0.02 μM) . MAO-B-IN-48 exhibits inhibitory activity against hBChE (IC50 = 1.10 μM, Ki = 0.43 μM) and AChE (IC50 = 0.56 μM, Ki = 0.14 μM) . MAO-B-IN-48 suppresses self-induced aggregation of toxic β-amyloid peptides and exerts antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. MAO-B-IN-48 can be used for the study of Alzheimer's disease (AD) [1].

Product Specifications

UNSPSC

12352100

Target

Amyloid-β; Cholinesterase (ChE) ; Monoamine Oxidase

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C[C@H](C1=CC=CC2=C1C=CC=C2)NC(OC3=CC(N(C)C)=CC=C3)=S

Molecular Formula

C21H22N2OS

Molecular Weight

350.48

References & Citations

[1]Teke Tuncel S, et al. Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-β-amyloid (Aβ) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:117986.