SHP2-IN-42

SHP2-IN-42 is a src homology 2 domain-containing phosphatase 2 (SHP2) inhibitor with an IC50 of 15 nM. SHP2-IN-42 inhibits cell proliferation and induces apoptosis and G1 phase cell cycle arrest. SHP2-IN-42 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Phosphatase; SHP2

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C[C@@H]1OCC2([C@@H]1N)CCN(CC2)C3=NN4C=CC(C5=CC=C(C=C5)N6C=CC=C6C(O)=O)=C4C(N3C)=O

Molecular Formula

C27H30N6O4

Molecular Weight

502.56

References & Citations

[1]Zhang M, et al. Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting. Eur J Med Chem. 2025 Nov 15;298:117988.