NNRT-IN-11

NNRT-IN-11 (14l) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with EC50 values of 6.50 to 52.9 nM against WT and a panel of HIV-1 mutants. NNRT-IN-11 has antiviral activity[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

FC1=C(C=CC(NC2=NC=C(C3=COC=C3)C(OC4=C(C=C(C=C4C)/C=C/C#N)C)=N2)=C1)C#N

Molecular Formula

C26H18FN5O2

Molecular Weight

451.45

References & Citations

[1]Zhou Z, et al. Further exploring the tolerant region II: Identification of 2,4,5-trisubstituted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity. Eur J Med Chem. 2025 Nov 5;297:117992.