NNRT-IN-11
NNRT-IN-11 (14l) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with EC50 values of 6.50 to 52.9 nM against WT and a panel of HIV-1 mutants. NNRT-IN-11 has antiviral activity[1].
Product Specifications
UNSPSC
12352005
Target
HIV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
FC1=C(C=CC(NC2=NC=C(C3=COC=C3)C(OC4=C(C=C(C=C4C)/C=C/C#N)C)=N2)=C1)C#N
Molecular Formula
C26H18FN5O2
Molecular Weight
451.45
References & Citations
[1]Zhou Z, et al. Further exploring the tolerant region II: Identification of 2,4,5-trisubstituted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity. Eur J Med Chem. 2025 Nov 5;297:117992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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