PEX5-PEX14 PPI-IN-3

PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC50 of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC50 of 7.2 μM against Trypanosoma brucei (T. brucei) . PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[H]N(C1=CC2=C(N(C(C3=CC=CC=C3C2)=O)CC)C=C1)C(CC4=CC=C(C=C4)F)=O

Molecular Formula

C24H21FN2O2

Molecular Weight

388.43

References & Citations

[1]Nowacki M, et al. Quantum mechanics-driven structure-activity relationship study of PEX5-PEX14 protein-protein interaction inhibitors based on a dibenzo [b, e] azepin-6 (6H) -one scaffold. European Journal of Medicinal Chemistry, 2025: 117979.