Dual FXR/PPARδ agonist-2
Dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC50 of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model[1].
Product Specifications
UNSPSC
12352005
Target
FXR; PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
CC1=NOC(C2=CC=C(C=C2)CN(C)C)=C1COC(N3CCN(CC3)C4=NN5C(C(O)=O)=CN=C5C=C4)=O
Molecular Formula
C26H29N7O5
Molecular Weight
519.55
References & Citations
[1]Yue L, et al. Rational design and synthesis of 6- (piperazin-1-yl) imidazo[1,2-b]pyridazine derivatives as dual FXR/PPARδ agonists for treatment of pulmonary fibrosis. Eur J Med Chem. 2025 Nov 15;298:118013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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