5-HT2C agonist-11
5-HT2C agonist-11 (Compound 1) is an orally active, brain-penetrant and selective 5-HT2C receptor agonist (EC50=15 nM) . 5-HT2C agonist-11 activates the Gq protein signaling pathway, promoting intracellular calcium release. 5-HT2C agonist-11 is promising for research of depression, post-traumatic stress disorder (PTSD) and neuropathic pain[1].
Product Specifications
CAS Number
3006787-99-8
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C2NC3=C(C2=C(C=C1)O)CCNCC3
Molecular Formula
C13H16N2O
Molecular Weight
216.28
References & Citations
[1]Sabnis RW. Novel Azepinoindoles as 5‑HT2C Agonists for Treating Depression, Drug Addiction, Alcoholism, PTSD, and Neuropathic Pain. ACS Med Chem Lett. 2025 Jul 28;16 (8) :1507-1508.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4088802 1.0 µg DNA
Mcts2 sgRNA CRISPR Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details 
VAng-Cr7350-500gEcoli 500 µg (E. coli)
Recombinant Pasteurella Multocida rpsS Protein (aa 2-91)
Sign In for Pricing
View Details C2255-27S-ML405 100 µL
CD4 (CD4 Receptor, CD4mut, T Cell Surface Antigen T4/Leu3, T Cell Surface Glycoprotein CD4 (MaxLight 405) discontinued
Sign In for Pricing
View Details 
12-9384B-100 100 µg
Biotinylated Anti-IL18RA antibody (DM218) ; Rabbit mAb
Sign In for Pricing
View Details