ZWZH-21
ZWZH-21 is a selective and orally active HDAC1/2 dual inhibitor with IC50 values of 34 nM for HDAC1 and 41 nM for HDAC2. ZWZH-21 can inhibit HCT116 and SW480 cells growth with IC50 values of 0.524 μM and 1.063 μM, respectively. ZWZH-21 can inhibit proliferation and migration and induces apoptosis in multiple colorectal cancer cells. ZWZH-21 can be used for the research of cancer, such as colorectal cancer[1].
Product Specifications
CAS Number
3069195-42-9
UNSPSC
12352005
Target
Apoptosis; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=C(N)C=CC=C1)C2=CC=C(OCCN3C(C=NC=C4)=C4C5=C3C=CC=C5)C=C2
Molecular Formula
C26H22N4O2
Molecular Weight
422.48
References & Citations
[1]Wang Z, et al. Design, synthesis, and antitumor activity study of β-carboline derivatives as selective HDAC1/2 inhibitors. Bioorg Chem. 2025 Aug;163:108763.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
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