TREM2 agonist-5

TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

TREM receptor

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.75

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1N=CC(C2C=C(C3=NC(C4=CC=C(Cl)C=C4F)=C(N=C(C)C(C)=N5)C5=C3)CCO2)=C1

Molecular Formula

C24H21ClFN5O

Molecular Weight

449.91

References & Citations

[1]Yuan S, et al. Discovery of a Small Molecule TREM2 Agonist with Improved In Vitro Pharmacokinetic Profile and Validated Target Engagement. ACS Med Chem Lett. 2025 Jul 29;16 (8) :1634-1640.