NMDA receptor modulator 9
NMDA receptor modulator 9 is an orally active NMDA receptor positive allosteric modulator (PAM) . NMDA receptor modulator 9 enhances GluN2A receptor activity. NMDA receptor modulator 9 demonstrates significant antidepressant-like effects in chronic restraint stress (CRS) -induced depression mice. NMDA receptor modulator 9 can be used for the study of depression[1].
Product Specifications
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
FC1=CC=C(C2(O)CCN(CC3=CC(N4C=C(SC4=N3)C)=O)CC2)C=C1
Molecular Formula
C19H20FN3O2S
Molecular Weight
373.44
References & Citations
[1]Yang T, et al. AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression. J Med Chem. 2025 Aug 14;68 (15) :16260-16283.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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