NMDA receptor modulator 9

NMDA receptor modulator 9 is an orally active NMDA receptor positive allosteric modulator (PAM) . NMDA receptor modulator 9 enhances GluN2A receptor activity. NMDA receptor modulator 9 demonstrates significant antidepressant-like effects in chronic restraint stress (CRS) -induced depression mice. NMDA receptor modulator 9 can be used for the study of depression[1].

Product Specifications

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

FC1=CC=C(C2(O)CCN(CC3=CC(N4C=C(SC4=N3)C)=O)CC2)C=C1

Molecular Formula

C19H20FN3O2S

Molecular Weight

373.44

References & Citations

[1]Yang T, et al. AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression. J Med Chem. 2025 Aug 14;68 (15) :16260-16283.