Dopamine D3 receptor antagonist-3
Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R) -selective positive allosteric modulator (PAM) -antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated β-arrestin recruitment assay with an IC50 and a Kd of 2.5 μM and 0.49 μM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].
Product Specifications
CAS Number
2894793-37-2
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
ClC(C=C1NS(C(C(C(N(C2)CCC2(F)F)=O)=C3C)=C(N3)C)(=O)=O)=C(C=C1)C(F)(F)F
Molecular Formula
C18H17ClF5N3O3S
Molecular Weight
485.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor
Frequently Asked Questions
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