MGD-22
MGD-22, a molecular glue, is an orally active IKZF1/2/3 degrader with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. MGD-22 exhibits extremely potent anti-proliferative activity against diverse hematological cancer cells. MGD-22 induces apoptosis in cancer cells. MGD-22 demonstrates potent anti-tumor efficacy in mice bearing NCI-H929 xenografts or WSU-DLCL-2 xenografts. MGD-22 can be used for the study of hematological cancers, including multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL) [1].
Product Specifications
CAS Number
[2991818-12-1]
UNSPSC
12352005
Target
Apoptosis; IKZF Family; Molecular Glues
Related Pathways
Apoptosis; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N1)C(N2N(CC3=C(C=CC=C3C2=O)NCC4=CC=C(CN5CCN(CC5)C6=CC=C(C=C6)C#N)C=C4)C)CCC1=O
Molecular Formula
C33H35N7O3
Molecular Weight
577.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF1; IKZF2; IKZF3
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