Succinate dehydrogenase-IN-11

Succinate dehydrogenase-IN-11 (Compound A12) is a succinate dehydrogenase inhibitor with an IC50 value of 3.58 μM. Succinate dehydrogenase-IN-11 exhibits antifungal activity. Succinate dehydrogenase-IN-11 shows activity against fungi such as R. solani, B. cinerea, F. graminearum, and S. sclerotiorum in vitro. Succinate dehydrogenase-IN-11 also exerts a controlling effect on R. solani, P. pachyrhizi, and P. sorghi in vivo. Succinate dehydrogenase-IN-11 can be used in research related to antifungal applications[1].

Product Specifications

UNSPSC

12352005

Target

Fungal; Succinate Dehydrogenase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2C#CC3=CC=CC(F)=C3

Molecular Formula

C20H14F3N3O

Molecular Weight

369.34

References & Citations

[1]Qian J, et al. Discovery of Succinate Dehydrogenase Inhibitors Containing a Diphenylacetylene Fragment as Antifungal Agents. J Agric Food Chem. 2025 Aug 13;73 (32) :19983-19992.