Acid Ceramidase-IN-3

Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC 50 of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1. KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1, PDGF-D, PDGFR-B) . Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases[1].

Product Specifications

CAS Number

[2907705-12-6]

UNSPSC

12352005

Target

Ceramidase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N1C=C(N=C1)C2=CC=C(C=C2)OCC3=CC=C(C=C3)F)NCCCCC4=CC=CC=C4

Molecular Formula

C27H26FN3O2

Molecular Weight

443.51

References & Citations

[1]Beresis R, et al. Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases. ACS Omega. 2025 Jul 31;10 (31) :34747-34761.