6PGD-IN-2
6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 μM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(NC1=NN=C(C2=CC=C(Br)C=C2F)S1)CC3=CC=C(Cl)C(Cl)=C3
Molecular Formula
C16H9BrCl2FN3OS
Molecular Weight
461.14
References & Citations
[1]Zhang R, et al. Discovery of N- (1,3,4-Thiadiazol-2-yl) amide Derivatives as Uncompetitive Inhibitors of 6-Phosphogluconate Dehydrogenase. J Med Chem. 2025 Aug 14;68 (15) :15403-15421.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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