HIV-1-IN-85
HIV-1-IN-85 is an orally active HIV-1 inhibitor (IC50 = 72 nM) . HIV-1-IN-85 exhibits strong inhibitory activity against wild-type (WT) HIV-1 and NNRTI-resistant single mutant strains (L100I, K103N, Y181C, Y188L, E138K) and moderate efficacy against double mutant strains (F227L+V106A, RES056) . HIV-1-IN-85 shows good in vivo safety in ICR mice. HIV-1-IN-85 can be used for the study of HIV-1 infection[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC1=CC(C2=CC=C(C=C2)C#N)=CC(C)=C1[C@@H](C3=CC=NC(NC4=CC=C(C=C4)C#N)=N3)F
Molecular Formula
C27H20FN5
Molecular Weight
433.48
References & Citations
[1]Chen XM, et al. Halogenation-Driven Discovery of Halomethylene-Biphenyl-Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Safety and PK Profiles. J Med Chem. 2025 Aug 14;68 (15) :15358-15371.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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