HIV-1-IN-85

HIV-1-IN-85 is an orally active HIV-1 inhibitor (IC50 = 72 nM) . HIV-1-IN-85 exhibits strong inhibitory activity against wild-type (WT) HIV-1 and NNRTI-resistant single mutant strains (L100I, K103N, Y181C, Y188L, E138K) and moderate efficacy against double mutant strains (F227L+V106A, RES056) . HIV-1-IN-85 shows good in vivo safety in ICR mice. HIV-1-IN-85 can be used for the study of HIV-1 infection[1].

Product Specifications

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=CC(C2=CC=C(C=C2)C#N)=CC(C)=C1[C@@H](C3=CC=NC(NC4=CC=C(C=C4)C#N)=N3)F

Molecular Formula

C27H20FN5

Molecular Weight

433.48

References & Citations

[1]Chen XM, et al. Halogenation-Driven Discovery of Halomethylene-Biphenyl-Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Safety and PK Profiles. J Med Chem. 2025 Aug 14;68 (15) :15358-15371.