RORγ inverse agonist 2

RORγ inverse agonist 2 (Compound 15) is a potent inverse agonist of the retinoic acid receptor-related orphan receptor RORγ, with IC50 values of 0.4 and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. RORγ inverse agonist 2 is useful in the study of autoimmune diseases[1].

Product Specifications

CAS Number

[1242610-59-8]

UNSPSC

12352005

Target

ROR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

CC1(C)C(/C(C[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C\C6=CC=CO6)=O

Molecular Formula

C35H48O4

Molecular Weight

532.75

References & Citations

[1]Schwarz PF, et al. Identification of New Lupane-Type Triterpenoids as Inverse Agonists of RAR-Related Orphan Receptor Gamma (RORγ) . J Nat Prod. 2025 Aug 22;88 (8) :1887-1900.