RPX 7546
RPX 7546 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 1.4 and 48 μM for IMP-1 and IMP-78, respectively. RPX 7546 has antibacterial activity[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(C1=C(OB(O)C(SC2=NN=CS2)C3)C3=CC=C1OC)O
Molecular Formula
C12H11BN2O5S2
Molecular Weight
338.17
References & Citations
[1]Thomas CA, et al. Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-β-Lactamases: Analysis and Implications for Inhibitor Design. ACS Infect Dis. 2025 Aug 8;11 (8) :2157-2168.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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