A2AAR antagonist 4
A2AAR antagonist 4 is an orally active A2A Adenosine receptor antagonist with a Ki of 0.36 nM and a KB of 1 nM at hA2AAR. A2AAR antagonist 4 fully inhibits hA2AAR and hA2bAR at 10 μM. A2AAR antagonist 4 can be used for research of cancer, such as MC38 tiumor[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@@H]1CCO[C@H]1N2C3=C(N=C2C4=CC=CO4)C(N)=NC(C#CCCCC)=N3
Molecular Formula
C19H21N5O3
Molecular Weight
367.40
References & Citations
[1]Kim G, et al. Regio- and Stereoselective Ribose Modification in Truncated 2,8-Disubstituted Adenosine Scaffold to Develop Highly Potent A2AAdenosine Receptor Antagonists. J Med Chem. 2025 Aug 14;68 (15) :16802-16818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)
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