TrkB activator-1

TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor) -Tropomyosin-related kinase B (TrkB) -CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression[1].

Product Specifications

CAS Number

[3087336-56-6]

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Trk Receptor

Related Pathways

Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Neurological Disease

Smiles

O=C(N[C@H](C1=NC=CO1)C(C)C)[C@H]2CCN2C(C([2H])([2H])[2H])=O

Molecular Formula

C13H16D3N3O3

Molecular Weight

268.33

References & Citations

[1]Cheng X, et al. Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling. J Med Chem. 2025 Aug 14;68 (15) :16781-16801.