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PARP1-IN-43

PARP1-IN-43 (Compound 5350) is a blood-brain barrier (BBB) permeable PARP1 inhibitor, with an IC50 of 5 nM. PARP1-IN-43 can be used for the study of homologous recombination (HR) -deficient central nerve system (CNS) cancers[1].

Product Specifications

CAS Number

3066798-40-8

UNSPSC

12352005

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer; Neurological Disease

Smiles

CC(N1CCCC(C1)C(N2CCN(CC2)C(C3=CC4=C(C(C5=C6CNC(C6=CC=C5)=O)=CC=C4)O3)=O)=O)=O

Molecular Formula

C29H30N4O5

Molecular Weight

514.57

References & Citations

[1]Zhou X, et al. Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment. ACS Med Chem Lett. 2025 Jul 24;16 (8) :1497-1498.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1

Frequently Asked Questions

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