PARP1-IN-43
PARP1-IN-43 (Compound 5350) is a blood-brain barrier (BBB) permeable PARP1 inhibitor, with an IC50 of 5 nM. PARP1-IN-43 can be used for the study of homologous recombination (HR) -deficient central nerve system (CNS) cancers[1].
Product Specifications
CAS Number
[3066798-40-8]
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Neurological Disease
Smiles
CC(N1CCCC(C1)C(N2CCN(CC2)C(C3=CC4=C(C(C5=C6CNC(C6=CC=C5)=O)=CC=C4)O3)=O)=O)=O
Molecular Formula
C29H30N4O5
Molecular Weight
514.57
References & Citations
[1]Zhou X, et al. Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment. ACS Med Chem Lett. 2025 Jul 24;16 (8) :1497-1498.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7140094 Inquire
Rabbit anti-Schizosaccharomyces pombe (strain 972/24843)(Fission yeast) LSM1 Polyclonal Antibody
Ask
View Details TA506178AM 100 µL
Cytochrome C Oxidase subunit VIc (COX6C) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4A5]
Ask
View Details ![CEACAM5 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C2]](https://cdn.genprice.uk/products/937/6868c3bb994c49e6dc3fd373/imageurl/ta803415am.webp)
TA803415AM 100 µL
CEACAM5 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C2]
Ask
View Details GTR15390278 1 Vial
Lentiviral human P2RX1 sgRNA gene knockout kit - Lentiviral human P2RX1 sgRNA gene knockout kit (plasmid)
Ask
View Details