PARP1-IN-43
PARP1-IN-43 (Compound 5350) is a blood-brain barrier (BBB) permeable PARP1 inhibitor, with an IC50 of 5 nM. PARP1-IN-43 can be used for the study of homologous recombination (HR) -deficient central nerve system (CNS) cancers[1].
Product Specifications
CAS Number
3066798-40-8
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Neurological Disease
Smiles
CC(N1CCCC(C1)C(N2CCN(CC2)C(C3=CC4=C(C(C5=C6CNC(C6=CC=C5)=O)=CC=C4)O3)=O)=O)=O
Molecular Formula
C29H30N4O5
Molecular Weight
514.57
References & Citations
[1]Zhou X, et al. Novel Isoindolinone-Containing PARP Inhibitors: Synthesis and Therapeutic Applications in CNS Cancer Treatment. ACS Med Chem Lett. 2025 Jul 24;16 (8) :1497-1498.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
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