GLPG4970

GLPG4970 is a potent, selective and orally active salt-inducible kinase 2/3 (SIK2/SIK3) dual inhibitor with IC50 values of 0.3 nM and 0.7 nM. GLPG4970 has weak inhibition of hERG channel with an IC50 of 29 μM. GLPG4970 can decrease TNFα release and increase IL-10 release GLPG4970 can be used for the researches of inflammation and immunology, such as colitis[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; Salt-inducible Kinase (SIK) ; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.6000

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(CC(F)(F)F)CCC2=C1C(OC)=CC(C3=CC(C4=CC5=C(C=C4)CC(C)(C)N(C)C5)=CN=C3N)=C2

Molecular Formula

C29H31F3N4O2

Molecular Weight

524.58

References & Citations

[1]Kelgtermans H, et al. Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor. J Med Chem. 2025 Aug 14;68 (15) :16551-16577.