UNC7437

UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC50 value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP4, InsP5, and InsP6 in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models[1].

Product Specifications

CAS Number

[2967647-41-0]

UNSPSC

12352005

Target

IPK Superfamily

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(O)/C=C/C1=CC2=C(C3=CC(C)=CC(C)=C3)ON=C2C=C1

Molecular Formula

C18H15NO3

Molecular Weight

293.32

References & Citations

[1]Zhou Y, et al. Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors. J Med Chem. 2025 Aug 14;68 (15) :15446-15460.