(GalNAc) 3-CPT
(GalNAc) 3-CPT is a glycoconjugate prodrug that targets the asialoglyco-protein receptor (ASGR) overexpressed on hepatocytes. (GalNAc) 3-CPT exhibits significant antitumor activity (IC50 value of 3.07 μM in HepG2 cells) by activating the cGAS-STING pathway and promoting CD8+ T cell infiltration into tumors, thereby inducing tumor cell apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O[C@@H]1[C@H]([C@@H](O[C@@H](C1O)CO)OCCCCC(NCCCNC(CCOCC(NC(CCCCCN2C=C(N=N2)CCCC(O[C@@]3(C(OCC4=C3C=C5C6=NC(C=CC=C7)=C7C=C6CN5C4=O)=O)CC)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]8[C@@H]([C@H](C([C@H](O8)CO)O)O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H]9[C@@H]([C@H](C([C@H](O9)CO)O)O)NC(C)=O)=O)=O)=O)=O)NC(C)=O
Molecular Formula
C93H141N15O33
Molecular Weight
1997.20
References & Citations
[1]Li Y, et al. A Soluble Triantennary N-Acetylgalactosamine Camptothecin Prodrug for Hepatocellular Carcinoma-Targeted Therapy. J Med Chem. 2025 Aug 14;68 (15) :15563-15578.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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