RNA polymerase-IN-3
RNA polymerase-IN-3 (Compound 28) is a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. RNA polymerase-IN-3 inhibits RNA synthesis by competitively blocking the binding of UTP to RNAP (IC50= 0.28 μM) . RNA polymerase-IN-3 is promising for research of bacterial infections[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
O[C@@H]1[C@H](O)[C@@H](CNC([C@H](CCC#N)N(O)C(CNC(C)=N)=O)=O)O[C@H]1C(C(N2)=O)=CNC2=O
Molecular Formula
C18H25N7O8
Molecular Weight
467.43
References & Citations
[1]Okawa R, et al. Structure-Activity Relationship of Pseudouridimycin Focusing on the Improvement of Chemical Stability. J Med Chem. 2025 Aug 14;68 (15) :15461-15482.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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