HDAC6/HSP90-IN-3
HDAC6/HSP90-IN-3 (Compound 17) is an orally active dual histone deacetylase 6 (HDAC6) and heat shock protein 90 (HSP90) inhibitor with IC50 values of 28 nM and 0.88 μM, respectively. HDAC6/HSP90-IN-3 is promising for research of malignant tumors such as prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
HDAC; HSP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1=CN=C(CN2C3=NC(N)=NC(Cl)=C3C(CC4=CC=C(C(NO)=O)C=C4)=C2)C(C)=C1OC
Molecular Formula
C23H23ClN6O3
Molecular Weight
466.92
References & Citations
[1]Citarella A, et al. Structure-Based Discovery of Hsp90/HDAC6 Dual Inhibitors Targeting Aggressive Prostate Cancer. J Med Chem. 2025 Aug 14;68 (15) :15738-15765.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; HSP90
Frequently Asked Questions
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