SMI-10B13

SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively) . SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1].

Product Specifications

CAS Number

[2502294-68-8]

UNSPSC

12352005

Target

Interleukin Related; STAT

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(/C=C/C1=CC(C2=CC3=C(C=C2)C=CN3)=C(O1)C4=CC=C5C=CNC5=C4)O

Molecular Formula

C23H16N2O3

Molecular Weight

368.38

References & Citations

[1]Wolf CL, et al. Development of the First Small-Molecule Inhibitor Targeting Oncostatin M for Treatment of Breast Cancer. J Med Chem. 2025 Aug 14;68 (15) :15422-15445.