AR-DBD ligand-Linker Conjugate 1

AR-DBD ligand-Linker Conjugate 1 is a conjugate of AR-DBD ligand and linker. AR-DBD ligand-Linker Conjugate 1 can be used to synthesize PROTAC LYA914 (HY-175455) [1].

Product Specifications

UNSPSC

12352005

Target

Androgen Receptor; Target Protein Ligand-Linker Conjugates

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=C(F)C(F)=CC=C1C2=CSC(N3CCN(C4CCN(CC5CCNCC5)CC4)CC3)=N2

Molecular Formula

C25H35F2N5OS

Molecular Weight

491.64

References & Citations

[1]Lv Y, et al. Discovery of LYA914, An Orally Bioavailable PROTAC Degrader Targeting the DNA Binding Domain of the Androgen Receptor for the Treatment of CRPC. J Med Chem. 2025 Jul 28.