MRT-3486
MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues; NEKs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Purity
99.6200
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(S(=O)(CC2=CC=CC=C2)=O)CC3=C(C=CC=C3)C1)NCC4=CC5=NC=C(N(C(N6)=O)CCC6=O)N5C=C4
Molecular Formula
C29H28N6O5S
Molecular Weight
572.63
References & Citations
[1]Petzold G, et al. Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition. Science. 2025 Jul 3;389 (6755) :eadt6736.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK7
Available Sizes
Frequently Asked Questions
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