XIAP ligand-Linker Conjugate 2

XIAP ligand-Linker Conjugate 2 is an E3 ligase ligand-linker conjugate that incorporates the XIAP BIR2 ligand XB2M54 (HY-175348) and linker. XIAP ligand-Linker Conjugate 2 can be used for synthesis of PROTAC GNE-1567 (HY-175448) [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates; IAP

Related Pathways

Apoptosis; PROTAC

Field of Research

Cancer

Smiles

OC(CCOCCOCCC(N1C2=C(N(C([C@H]([C@@H]1C)NC([C@@H](NC)C)=O)=O)CC3=C(C=CC4=C3C=CC(Br)=C4)OC)C=CC(C#N)=C2)=O)=O

Molecular Formula

C35H40BrN5O8

Molecular Weight

738.62

References & Citations

[1]Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32 (5) :694-709.e35.