XIAP ligand 5
XIAP ligand 5 is a XIAP antagonist. XIAP ligand 5 is an E3 ligase ligand. XIAP ligand 5 can be used for synthesis of PROTAC GNE-1567 (HY-175448) [1].
Product Specifications
UNSPSC
12352005
Target
IAP; Ligands for E3 Ligase
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
CC(N1C2=C(N(C([C@H]([C@@H]1C)NC([C@@H](NC)C)=O)=O)CC3=C(C=CC4=C3C=CC(Br)=C4)OC)C=CC(C#N)=C2)=O
Molecular Formula
C29H30BrN5O4
Molecular Weight
592.48
References & Citations
[1]Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32 (5) :694-709.e35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
XIAP
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