GNE-1567

GNE-1567 is a potent ERα PROTAC degrader and a selective XIAP antagonist with a Kd value of 0.03 μM. GNE-1567 is indicated for breast cancer research. (Pink: ligand for target protein (HY-18719) ; Black: linker; Blue: ligand for E3 ligase (HY-175449) ) [1].

Product Specifications

UNSPSC

12352005

Target

Estrogen Receptor/ERR; IAP; PROTACs

Related Pathways

Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(N4C5=C(N(C([C@H]([C@@H]4C)NC([C@@H](NC)C)=O)=O)CC6=C(C=CC7=C6C=CC(Br)=C7)OC)C=CC(C#N)=C5)=O)=O)C

Molecular Formula

C60H65BrN6O9

Molecular Weight

1094.10

References & Citations

[1]Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32 (5) :694-709.e35.