GDC-0152-acetamide
GDC-0152-acetamide is a pan-inhibitor of apoptosis protein (IAP) antagonist. GDC-0152-acetamide induces cIAP1/2 autoubiquitination and degradation, activating the non-canonical NF-κB pathway to promote TNF-α secretion and tumor cell apoptosis. GDC-0152-acetamide is promising for research of ERα-positive breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; IAP
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CC(NC1=NC(C2=CC=CC=C2)=C(NC([C@@H]3CCCN3C([C@@H](NC([C@H](C)NC)=O)C4CCCCC4)=O)=O)S1)=O
Molecular Formula
C28H38N6O4S
Molecular Weight
554.70
References & Citations
[1]Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32 (5) :694-709.e35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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