Carbonic anhydrase activator 1

Carbonic anhydrase activator 1 (Compound 17) is an orally active and a BBB-penetrable Carbonic anhydrase (CA) activator with KAs of 7.8, 3.9 and 2.1 μM for hCA I, hCA VA and hCA VII. Carbonic anhydrase activator 1 can be used for cancers, glaucoma, cardiovascular diseases and neurodegenerative disorders like epilepsy research[1].

Product Specifications

CAS Number

[2374923-30-3]

UNSPSC

12352005

Target

Carbonic Anhydrase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

N#CC1=C(C2=CC=CO2)C(C#N)=C(N)N=C1SCC3=CC=NC=C3

Molecular Formula

C17H11N5OS

Molecular Weight

333.37

References & Citations

[1]Vigiani E, et al. Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators. Eur J Med Chem. 2025 Jul 5;291:117578.