CST905
CST905 is a potent PROTAC degrader of BRAF-V600E with a DC50 of 18 nM. CST905 is suitable for cancer research. (Structure Note: Pink: target protein ligand (HY-41747) ; Blue: E3 ligase ligand (HY-125845) ; Black: linker (HY-78378) ) [1].
Product Specifications
CAS Number
[3094183-98-6]
UNSPSC
12352005
Target
PROTACs; Raf
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(N(CC)C)=O)=C6F)=O)C5=C4)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Molecular Formula
C51H58F2N10O7S2
Molecular Weight
1025.20
References & Citations
[1]Miller DSJ, et al. Encoding BRAF inhibitor functions in protein degraders. RSC Med Chem. 2022 May 5;13 (6) :731-736.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Curated Selection
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