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TNF-α-IN-26

TNF-α-IN-26 (Compound 18) is a TNF-α inhibitor with an IC50 of 0.10 μM for CSBP ligands. TNF-α-IN-26 inhibits LPS -stimulated TNF production in mice model. TNF-α-IN-26 can be used for inflammatory diseases research[1].

Product Specifications

CAS Number

165806-63-3

UNSPSC

12352005

Target

TNF Receptor

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Smiles

FC1=CC=C(C2=C(C3=CC=NC=C3)N(CCCOCC)C=N2)C=C1

Molecular Formula

C19H20FN3O

Molecular Weight

325.38

References & Citations

[1]Boehm JC, et al. 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency. J Med Chem. 1996 Sep 27;39 (20) :3929-37.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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