P38 MAPK-IN-7
P38 MAPK-IN-7 (Compound 2) is an orally active, potent and selective p38 MAP kinase inhibitor (IC50=170 nM) . p38 MAPK-IN-7 is promising for research of inflammatory diseases such as rheumatoid arthritis and septic shock[1].
Product Specifications
CAS Number
[165806-50-8]
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C2=C(C3=CC=NC(N)=N3)N(C(C)C)C=N2)C=C1
Molecular Formula
C16H16FN5
Molecular Weight
297.33
References & Citations
[1]Adams JL, et al. Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. Bioorg Med Chem Lett. 2001 Nov 5;11 (21) :2867-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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