Antifolate agent 1

Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates[1].

Product Specifications

CAS Number

[518063-75-7]

UNSPSC

12352005

Target

Antifolate

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C1C2=C(NC(N)=N1)NC(CC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=C2

Molecular Formula

C19H19N5O6

Molecular Weight

413.38

References & Citations

[1]Deng Y, et al. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem. 2008 Aug 28;51 (16) :5052-63. |[2]Deng Y, et al. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem. 2008 Aug 28;51 (16) :5052-63.