K-757
K-757 is a GPR40 agonist with an EC50 of 2.1 ± 0.2 nM for human GPR40. K-757 exhibits a half-life of 1-11 h in Preclinical Species. K-757 stimulates GLP-1 secretion and has potential applications in bariatric research[1].
Product Specifications
UNSPSC
12352005
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
O=P(CC[C@@H](C1CC1)C2=CC=CC(OCC3CCN(C4=CC(OC)=CC=C4CCCC(C)(C)C)CC3)=C2)O
Molecular Formula
C32H48NO4P
Molecular Weight
541.70
References & Citations
[1]Moyes CR, et al. Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175420/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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