K-757
K-757 is a GPR40 agonist with an EC50 of 2.1 ± 0.2 nM for human GPR40. K-757 exhibits a half-life of 1-11 h in Preclinical Species. K-757 stimulates GLP-1 secretion and has potential applications in bariatric research[1].
Product Specifications
UNSPSC
12352005
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
O=P(CC[C@@H](C1CC1)C2=CC=CC(OCC3CCN(C4=CC(OC)=CC=C4CCCC(C)(C)C)CC3)=C2)O
Molecular Formula
C32H48NO4P
Molecular Weight
541.70
References & Citations
[1]Moyes CR, et al. Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
