TBIA
TBIA (trans bis-isatoic anhydride) is a covalent RNA crosslinker. TBIA selectively induces RNA tertiary interactions (e.g., multi-helix junctions, loop-helix packing) . TBIA is promising for research of RNA higher-order structure and disease-associated RNAs (e.g., KRAS-mutant RNAs) [1].
Product Specifications
Product Name Alternative
Trans bis-Isatoic anhydride
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(NC(C1=C2)=CC3=C2NC(OC3=O)=O)OC1=O
Molecular Formula
C10H4N2O6
Molecular Weight
248.15
References & Citations
[1]Christy TW, et al. Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP. Biochemistry. 2021 Jun 29;60 (25) :1971-1982.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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