VHL-SNAP2-5C
VHL-SNAP2-5C is a SNAP-fusion protein PROTAC degrader basing on a self-labeling protein SNAP tag. VHL-SNAP2-5C by endogenous tagging enables the visualization and the selective depletion of a SNAP-fusion protein, such as CLCa andEGFP[1]. Pink: SNAP-fusion protein ligand (HY-W128709) ; Blue: VHL ligase ligand (HY-112078) ; Black: linker (HY-Y1139)
Product Specifications
UNSPSC
12352005
Target
PROTACs
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(COC2=NC(N)=NC(Cl)=C2)C=C1)CCCCCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C[C@@H](O)C3)=O)=O
Molecular Formula
C42H53ClN8O6S
Molecular Weight
833.44
References & Citations
[1]Pol SA, et al. Induced degradation of SNAP-fusion proteins. RSC Chem Biol. 2024 Oct 21;5 (12) :1232–47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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