Yoda2
Yoda2 (KC289) is the potassium salt of Yoda1. Yoda2 is an agonist of PIEZO1 with an EC50 of 150 nM. Yoda2 evokes Ca2+ elevation in HeLa cells. Yoda2 can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50 = 1.2 μM). Yoda2 can stimulate NOS3 and NO production[1].
Product Specifications
CAS Number
3081450-95-2
Product Name Alternative
KC289
UNSPSC
12352005
Target
NO Synthase; Piezo Channel
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.57
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O[K])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1
Molecular Formula
C16H9Cl2KN2O2S2
Molecular Weight
435.39
References & Citations
[1]Parsonage, G., et al., (2023) . Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. British journal of pharmacology, 180 (16), 2039–2063.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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