Yoda2

Yoda2 (KC289) is the potassium salt of Yoda1 (HY-18723) . Yoda2 is an agonist of PIEZO1 with an EC50 of 150 nM. Yoda2 evokes Ca2+ elevation in HeLa cells. Yoda2 can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50 = 1.2 μM) . Yoda2 can stimulate NOS3 and NO production[1].

Product Specifications

CAS Number

[3081450-95-2]

Product Name Alternative

KC289

UNSPSC

12352005

Target

NO Synthase; Piezo Channel

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.57

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O[K])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1

Molecular Formula

C16H9Cl2KN2O2S2

Molecular Weight

435.39

References & Citations

[1]Parsonage, G., et al., (2023) . Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. British journal of pharmacology, 180 (16), 2039–2063.