ICP-103

ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC50 of 30 nM. ICP-103 is promising for research of cancers[1][2].

Product Specifications

CAS Number

[153997-72-9]

UNSPSC

12352005

Target

PKC

Related Pathways

Epigenetics; TGF-beta/Smad

Field of Research

Cancer

Smiles

N#CCCN(C1=C2C(C(NC3=O)=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6

Molecular Formula

C24H16N4O2

Molecular Weight

392.41

References & Citations

[1]Kleinschroth J, Hartenstein J, Rudolph C, et al. Novel indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (1) : 55-60.|[2]Roy S, Eastman A, Gribble G W. Synthesis of 7‐keto‐Gö6976 (ICP‐103) [J]. Synthetic communications, 2005, 35 (4) : 595-601.